A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.
"Mechanical stimulus culture assay using MIGHTY."
(K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)
Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.
Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.
Atelocollagen sponge, MIGHTY
5 mm diameter × 3 mm sponges
Storage and Stability
Store at Room Temperature
Notice To Purchaser
REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.
Koken Co., Ltd. (Japan)