Koken Atelocollagen sponge, MIGHTY

  • $755.00
  • (Delivery from $95.00 )
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A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.


  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant


  • Retains structural rigidity during repeated compression loading of 10-20 kPa
  • Sized for 96 well plates


"Mechanical stimulus culture assay using MIGHTY."

(K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.

Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

Product Name

Atelocollagen sponge, MIGHTY

Catalog Number




  • KKN-CSM-25 — 25 pieces
  • KKN-CSM-50 — 50 pieces

Sponge Dimensions

5 mm diameter × 3 mm sponges

Storage and Stability

Store at Room Temperature



Notice To Purchaser

REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.


Koken Co., Ltd. (Japan)

  1. Shiozaki Y, et al. Enhanced in vivoosteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.