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Stemfactor bFGF is an approximate 17 kDa protein consisting of 155 amino acid residues.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"50 μg","offer_id":45980762865850,"sku":"03-0002","price":185.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemfactor-fgf-basic-human-recombinant-p203-162_medium_dbfcfa0d-2f5c-4f10-9927-2a8bb4f0e990.jpg?v=1781100653"},{"product_id":"stemab-alkaline-phosphatase-staining-kit-ii","title":"StemAb Alkaline Phosphatase Staining Kit II","description":"\u003cp\u003eAlkaline phosphatase (AP) is expressed at high levels in pluripotent stem cells. AP dephosphorylates nucleotides, proteins, and alkaloids under alkaline conditions. After staining, undifferentiated cells appear red or purple whereas differentiated cells appear colorless. The undifferentiated state of embryonic stem (ES) and induced pluripotent stem (iPS) cells can be characterized by a high level of alkaline phosphatase (AP) expression which, along with the expression of other surface markers, indicates undifferentiated cells with the potential to self-renew. AP is a hydrolase enzyme responsible for dephosphorylating molecules such as nucleotides, proteins, and alkaloids under alkaline conditions. When fixed ES or iPS cells are stained using the AP Staining Kit, undifferentiated cells appear red or purple, whereas differentiated cells appear colorless. 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As such, it is frequently used as a marker for undifferentiated ES cells or induced pluripotent stem (iPS) cells. Oct4 is one of the key transcription factors used to reprogram mouse and human fibroblasts to a pluripotent state. The Oct4 Antibody (Affinity Purified)was screened on human and mouse ES cells using immunocytochemistry and flow cytometry and selected as the best Oct4 antibody available for researchers needing to demonstrate pluripotency. Immunocytochemistry analysis of Oct4 on H1 human ES cells. Cells were treated with StemAb Oct4 Antibody (Affinity Purified) using a 1:100 dilution followed by a secondary Cy3 conjugated antibody (red). DAPI staining was performed to visualize nuclei (blue). Flow cytometry analysis of Oct4 on H1 human ES cells. Purple histogram represents Oct4 Antibody and open histogram represents isotype control at the same concentration.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980762013882,"sku":"09-0023","price":268.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemab-oct4-antibody-affinity-purified-rabbit-anti-mouse-human-p265-408_medium_9eab80f8-fd5d-4942-bc18-bc8c1386c58d.jpg?v=1781100628"},{"product_id":"stemfactor-activin-a-human-recombinant","title":"Stemfactor Activin A, Human Recombinant","description":"\u003cp\u003eStemfactor Activin A is a crystallography-grade preparation providing the highest purity available. Activin A is bi-modal in action having been shown to maintain pluripotency of stem cells and promote differentiation 1,2,3,4 . 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BMP-4 plays an important role in the differentiation of overlying ectodermal tissue. Inhibition of the BMP-4 signal causes the ectoderm to differentiate into the neural plate. In cultured stem cells, BMP-4 plays a distinct role in mouse and human embryonic stem (ES) cells. BMP-4 supports LIF as a positive factor for mouse ES cell self-renewal 4 . In contrast, BMP-4 induces extra-embryonic trophoblast differentiation in human pluripotent stem cells 5 . Stemfactor BMP-4 is a recombinant protein expressed and purified from human 293 cells as a glycosylated homodimer with a molecular mass of 34 kDa.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 μg","offer_id":45980762603706,"sku":"03-0007","price":297.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemfactor-bmp-4-human-recombinant-p205-164_medium_4dcf4385-43ea-4159-8b10-90a84275de36.jpg?v=1781100650"},{"product_id":"stemfactor-lif-human-recombinant","title":"Stemfactor LIF, Human Recombinant","description":"\u003cp\u003eRecombinant Human LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of embryonic stem cells by suppressing spontaneous differentiation 1,2 . Leukemia Inhibitory Factor (LIF) has additional functions such as cholinergic neuron differentiation, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo 3 . Human LIF is an approximate 20 kDa protein containing 202 amino acid residues and is active on both human and mouse cells.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 mL (10 μg\/mL)","offer_id":45980763127994,"sku":"03-0016","price":307.0,"currency_code":"USD","in_stock":true},{"title":"1 mL (100 μg\/mL)","offer_id":46329943392442,"sku":null,"price":1372.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemfactor-lif-human-recombinant-p208-168_medium_a69151f3-983b-46cd-88ba-4d59e7ba87df.jpg?v=1781100654"},{"product_id":"stemfactor-lif-mouse-recombinant","title":"Stemfactor LIF, Mouse Recombinant","description":"\u003cp\u003eMouse LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of mouse embryonic stem cells by suppressing spontaneous differentiation 1,2 . Leukemia Inhibitory Factor (LIF) has additional functions such as cholinergic neuron differentiation, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo . Mouse LIF is an approximate 20 kDa protein containing 202 amino acid residues.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 ml (10 μg\/mL)","offer_id":45980763160762,"sku":"03-0011","price":292.0,"currency_code":"USD","in_stock":true},{"title":"1 ml (100 μg\/mL)","offer_id":46329943228602,"sku":null,"price":1161.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemfactor-lif-mouse-recombinant-p207-167_medium_2b27ccac-e719-4970-8870-211b43bc33d9.jpg?v=1781100655"},{"product_id":"stemrna-human-ipsc-771-3g","title":"StemRNA Human iPSC 771-3G","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. Taking full advantage of the power of the 3 rd Gen Technology , these cells feature: No possibility of integration or retention of Reprogramming Vectors Immediate thawing into NutriStem hPSC XF Culture medium ( Cat. No. 01-0005 ) in iMatrix-511 substrate ( Cat. No. NP892-011 ) with easy conversion to other standard iPSC Media. The possibility of saving significant time compared to reprogramming your own cells. Cat. No.: RCRP005N Strain ID: RPChiPS7713G1 Donor Race: Caucasian Donor Sex: Male Donor Age: 32 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Blood (EPCs) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPS7713G1 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers and DAPI. 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No.: RCRP004N Strain ID: RPChiPS8023G1 Donor Race: Hispanic Donor Sex: Female Donor Age: 30 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Blood (EPCs) Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPS8023G1 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers and DAPI. Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763259066,"sku":"RCRP004N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-802-3g-p460-382_medium_51b79aa1-b5db-4682-91ae-a5e292280d38.png?v=1781100658"},{"product_id":"stemrna-human-ipsc-bl003","title":"StemRNA Human iPSC BL003","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. Taking full advantage of the power of the 3 rd Gen Technology , these cells feature: No possibility of integration or retention of Reprogramming Vectors Immediate thawing into NutriStem hPSC XF Culture medium ( Cat. No. 01-0005 ) in iMatrix-511 substrate ( Cat. No. NP892-011 ) with easy conversion to other standard iPSC Media. The possibility of saving significant time compared to reprogramming your own cells. Cat. No.: RCRP009N Strain ID: RPChiPSSK0011 Donor Race: Asian-Indian Donor Sex: Female Donor Age: 20 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Blood (EPCs) Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSBL003 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for pluripotency markers. 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No.: RCRP006N Strain ID: RPChiPSSK0011 Donor Race: Asian-Indian Donor Sex: Male Donor Age: 56 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK001.1 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for pluripotency markers. Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763357370,"sku":"RCRP006N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-sk001-1-p487-423_medium_29c4290d-a856-4d77-a154-57f4f47f2b56.jpg?v=1781100661"},{"product_id":"stemrna-human-ipsc-sk002-1","title":"StemRNA Human iPSC SK002.1","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. 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No.: RCRP0011N Strain ID: RPChiPSSK0032 Donor Race: Asian-Indian Donor Sex: Female Donor Age: 20 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma \u0026amp; RPChiPSSK0032 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers and DAPI.; Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763521210,"sku":"RCRP011N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-sk003-2-p493-429_medium_68f9168a-7562-4ed4-ab71-44655b6c5a55.jpg?v=1781100663"},{"product_id":"stemrna-human-ipsc-sk004-2","title":"StemRNA Human iPSC SK004.2","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. Taking full advantage of the power of the 3 rd Gen Technology , these cells feature: No possibility of integration or retention of Reprogramming Vectors Immediate thawing into NutriStem hPSC XF Culture medium ( Cat. No. 01-0005 ) in iMatrix-511 substrate ( Cat. No. NP892-011 ) with easy conversion to other standard iPSC Media. The possibility of saving significant time compared to reprogramming your own cells. Cat. No.: RCRP007N Strain ID: RPChiPSSK0042 Donor Race: Asian-Indian Donor Sex: Male Donor Age: 65 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK04.2 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for pluripotency markers. 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No.: RCRP010N Strain ID: RPChiPSSK005.3 Donor Race: Caucasian Donor Sex: Male Donor Age: 56 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK0053 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers and DAPI. Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763586746,"sku":"RCRP010N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-sk005-3-p492-428_medium_cb1d3dba-71fd-4d81-b24b-da6eba7ca8af.jpg?v=1781100666"},{"product_id":"stemrna-human-ipsc-sk006-4","title":"StemRNA Human iPSC SK006.4","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. 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No.: RCRP032N Strain ID: RPChiPSSK012 Donor Race: African American Donor Sex: Male Donor Age: 22 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK012 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers. Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763652282,"sku":"RCRP032N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-sk012-p533-521_medium_f27660d0-2440-48c0-a307-00791ceb9d34.jpg?v=1781100668"},{"product_id":"stemrna-human-ipsc-sk013","title":"StemRNA Human iPSC SK013","description":"\u003cp\u003eReady to use IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. 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No.: RCRP031N Strain ID: RPChiPSSK014 Donor Race: Asian Donor Sex: Male Donor Age: 46 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK014 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers. Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980763717818,"sku":"RCRP031N","price":1737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-human-ipsc-sk014-p525-506_medium_40bab7b6-9d44-4005-81f8-49089565fcf0.jpg?v=1781100673"},{"product_id":"stemrna-human-ipsc-sk015","title":"StemRNA Human iPSC SK015","description":"\u003cp\u003eReady to use Parkinson's Disease Patient IPS Cells made using the Cutting-Edge StemRNA 3 rd Gen Reprogramming Technology. Taking full advantage of the power of the 3 rd Gen Technology , these cells feature: No possibility of integration or retention of Reprogramming Vectors Immediate thawing into NutriStem hPSC XF Culture medium ( Cat. No. 01-0005 ) in iMatrix-511 substrate ( Cat. No. NP892-011 ) with easy conversion to other standard iPSC Media. The possibility of saving significant time compared to reprogramming your own cells. Cat. No.: RCRP037P Strain ID: RPChiPSSK015 Donor Race: Caucasian Donor Sex: Male Donor Age: 58 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Normal (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK015 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers. 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The possibility of saving significant time compared to reprogramming your own cells. Cat. No.: RCRP047N Strain ID: RPChiPSSK0161 Donor Race: Hispanic and African American Donor Sex: Male Donor Age: 26 Reprogramming Technology: StemRNA 3 rd Gen Tissue Source: Skin (Fibroblasts) Karyotype: Robertsonian Translocation (46 XY) Microbiology: Negative for bacteria, virus, mycoplasma RPChiPSSK0161 Cells were cultured in NutriStem hPSC XF Medium on iMatrix-511 and stained for common pluripotency markers. 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Find out more about the potential therapeutic advantages of iMSCs in our recent blog post \" The Therapeutic Advantage of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells (iMSCs) \" The corresponding clinical iPSC line, RPC-LLF-34-F3, is also available. Visit Clinical Stem Cell Services to learn about our GMP iPSC and MSC services or Contact Us to discuss how REPROCELL can help with your project. ReproMSC 10 cells feature: Immediate thawing into Phenol Red-free MSC NutriStem XF Culture medium ( Cat. No. 01-0007 ) on NutriCoat Attachment Solution ( Cat. No.05-0063 ) with easy conversion to other standard MSC Media. The possibility of saving significant time compared to isolating your own primary MSCs. Cat. No.: RCRP038 Strain ID: Repro MSC10 Donor Race: Caucasian Donor Sex: Female Donor Age: 22 MSC Source: Derived from iPSC Strain RPC-LLF-34-F3 Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma Repro MSC10 cells were cultured in MSC NutriStem XF Medium, Phenol Red-free ( Cat. No. 01-0007 ) Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980764209338,"sku":"RCRP038","price":668.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/repro-msc10-ipsc-derived-mscs-phenol-red-free-p553-547_medium_042e1adf-3c27-474f-8c7a-aae63ff41808.jpg?v=1781100686"},{"product_id":"repro-msc3-ipsc-derived-mscs","title":"Repro MSC3 iPSC-derived MSCs","description":"\u003cp\u003eReady-to-use, Research-grade Human iPSC-derived Mesenchymal Stem Cells (iMSCs) Repro MSC3 cells were generated from one of our StemRNA™ iPSC lines, RPChiPSSK003.2 (established from fibroblasts using the StemRNA 3 rd Gen Reprogramming Technology). iPSC-derived MSCs, sometimes called iMSCs, offer several advantages over primary MSCs, because iPSCs have a minimally invasive collection process and high proliferative capacity, and they are good candidates for gene editing. Find out more about their potential therapeutic advantages in our recent blog post \" The Therapeutic Advantage of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells (iMSCs) \" These cells (Also called Mesenchymal Stromal Cells) feature: Immediate thawing into MSC NutriStem XF Culture medium ( Cat. No. 01-0006 ) on NutriCoat Attachment Solution ( Cat. No.05-0063 ) with easy conversion to other standard MSC Media. The possibility of saving significant time compared to isolating your own primary MSCs. Cat. No.: RCRP026 Strain ID: RPChMSC003 Donor Race: Asian-Indian Donor Sex: Female Donor Age: 20 MSC Source: Derived from iPSC Strain RPChiPSSK003.2 (Cat No RCRP011N) Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma ReproMSC3 cells were cultured in MSC NutriStem XF Medium (Cat. No. 01-0006 ) Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980764242106,"sku":"RCRP025","price":668.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/repro-msc3-ipsc-derived-mscs-p517-468_medium_22262b2d-86a3-4598-8b56-90b848b167f8.jpg?v=1781100687"},{"product_id":"repro-msc4-ipsc-derived-mscs-phenol-red-free","title":"Repro MSC4 iPSC-derived MSCs, Phenol Red-Free","description":"\u003cp\u003eReady-to-use, Research-grade Human iPSC-derived Mesenchymal Stem Cells (iMSCs) Repro MSC4 cells were generated from one of our StemRNA™ iPSC lines, RPChiPSSK003.2 (established from fibroblasts using the StemRNA 3 rd Gen Reprogramming Technology). These cells do not contain Phenol Red, making them ideal for exosome research. iPSC-derived MSCs, sometimes called iMSCs, offer several advantages over primary MSCs, because iPSCs have a minimally invasive collection process and high proliferative capacity, and they are good candidates for gene editing. Find out more about their potential therapeutic advantages in our recent blog post \" The Therapeutic Advantage of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells (iMSCs) \" These cells (also called Mesenchymal Stromal Cells) feature: Immediate thawing into Phenol Red-free MSC NutriStem XF Culture medium ( Cat. No. 01-0007 ) on NutriCoat Attachment Solution ( Cat. No.05-0063 ) with easy conversion to other standard MSC Media. The possibility of saving significant time compared to isolating your own cells. Cat. No.: RCRP026 Strain ID: RPChMSC003 Donor Race: Asian-Indian Donor Sex: Female Donor Age: 20 MSC Source: Derived from iPSC Strain RPChiPSSK003.2 (Cat No RCRP011N) Karyotype: Normal (46 XX) Microbiology: Negative for bacteria, virus, mycoplasma ReproMSC4 cells were cultured in MSC NutriStem XF Medium, Phenol Red-free ( Cat. No. 01-0007 ). Product Specifications\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980764274874,"sku":"RCRP026","price":668.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/repro-msc4-ipsc-derived-mscs-phenol-red-free-p516-466_medium_cc9bf08b-a598-4cb7-b64d-6295ca1236b9.jpg?v=1781100688"},{"product_id":"c-myc-mrna-human","title":"c-Myc mRNA, Human","description":"\u003cp\u003eStemgent c-Myc mRNA encodes the c-Myc protein commonly used in cellular reprogramming systems for the generation of induced pluripotent stem (iPS) cells. This_in vitro_transcribed mRNA incorporates both pseudouridine and 5-methylcytidine modified nucleotides to minimize the cellular interferon response to single stranded RNA. 1,2 Repeated transfection of c-Myc mRNA in combination with mRNAs encoding Oct4, Klf4, Sox2 and Lin-28 has been shown to reprogram human fibroblasts. 2 Figure 1 : Protein expression and localization shown by immunocytochemistry, DAPI in blue, c-Myc in red.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 vial","offer_id":45980764340410,"sku":"05-0018","price":340.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/c-myc-mrna-human-p257-174_medium_28e7ac2c-f0ab-4251-97e7-0eaf82ea7f46.png?v=1781100690"},{"product_id":"stemrna-3rd-gen-reprogramming-kit","title":"StemRNA 3rd Gen Reprogramming Kit","description":"\u003cp\u003eThird Generation RNA Kit for Cellular Reprogramming of Fibroblasts, Blood, and Urine The latest evolution in Stemgent RNA reprogramming, the StemRNA 3 rd Gen Reprogramming Kit (formerly called the StemRNA-NM Reprogramming Kit), combines non-modified RNA and microRNA technology to provide a kit for stem cell researchers with a new level of versatility, simplicity and time savings, enabling cellular reprogramming of human fibroblasts, and cells from blood and now urine for difficult to reprogram patient samples. Key Benefits Flexible technology generates high-quality human iPS cell lines from multiple target cell types Out-of-the-box reprogramming of cells from skin (fibroblasts), blood (endothelial progenitor cells; EPCs) and urine (urine-derived progenitor cells; UPCs) High efficiency, non-integrating reprogramming StemRNA-3 rd Gen requires a few as four additional reagents. Double stranded microRNAs enhance reprogramming efficiency, providing iPS cells with high efficiency (up to 4% from fibroblasts, up to 3% from EPCs, up to 0.5% from UPCs). Time-saving protocol delivers faster results facilitating higher throughput Colonies ready to pick in 10-14 days from fibroblasts and 12-16 days from EPCs or UPCs. No screening needed StemRNA-3 rd Gen Reprogramming Kit (00-0076) Feature Fibroblasts Urine (UPCs) Blood (EPCs) No. wells per kit 9 3 3 No Transfections required 4 6-8 6-8 Days to primary iPS cell colonies 10-14 12-14 12-14 Reprogramming efficiency 2-4% 0.1-0.5% 0.4-3% Screening Required No No No Xeno-compatible protocol Yes No No P7 primary iPS cells derived from UPCs were stained using the StainAlive TRA-1-60 Antibody ( Cat. No. 09‑0068 ) and DAPI after expansion in NutriStem hPSC XF Medium ( Cat. No. 01‑0005 ) iPS cells derived from fibroblasts using the StemRNA-3 rd Gen Reprogramming Kit were cultured on iMatrix-511 (Cat. No. NP892‑011) in NutriStem hPSC XF Medium ( Cat. No. 01‑0005 ) for 7 passages. Magnification: 4x Timeline for StemRNA 3 rd reprogramming of fibroblasts Download our StemRNA-3 rd Gen Reprogramming Posters: ISSCR 2015 ISSCR 2016\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 kit","offer_id":45980764373178,"sku":"00-0076","price":1750.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemrna-3rd-gen-reprogramming-kit-p198-235_medium_1f5a8c96-15ab-44b5-84dc-b6a9426c39a5.jpg?v=1781100691"},{"product_id":"hes-cell-cloning-recovery-supplement","title":"hES Cell Cloning \u0026 Recovery Supplement","description":"\u003cp\u003eThe hES Cell Cloning and Recovery Supplement is a 1000X concentrate supplement that contains Thiazovivin at 2mM concentration. The hES Cell Cloning and Recovery Supplement can be used in several areas of cell culture to enhance productivity and efficiency. The addition of the hES Cell Cloning and Recovery Supplement to cell culture media significantly improves the likelihood of successful sub-cloning from single cells 1,2 . This supplement was validated at a working concentration of 2 uM, however optimal conditions can vary and should be determined by the user.When added during a thaw, this supplement boosts recovery and thawing efficiency. The use of the hES Cell Cloning and Recovery Supplement also increases attachment after passaging. The hES Cell Cloning and Recovery Supplement is a valuable tool for escalating efficiency when working with human embryonic stem (hES) and human induced pluripotent stem (hiPS) cells under stressful conditions.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 x 100 μl","offer_id":45980764569786,"sku":"01-0014-500","price":208.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/hes-cell-cloning-recovery-supplement-p201-69_medium_6bf1447a-99b8-4155-bb8a-6f2c2d30655f.png?v=1781100692"},{"product_id":"stemolecule-a83-01","title":"Stemolecule A83-01","description":"\u003cp\u003eA83-01 is a selective inhibitor of the transforming growth factor-β (TGFβ) type I receptor ALK5, the Activin\/Nodal receptor ALK4, and the nodal receptor ALK7 1 . This molecule is more potent than SB431542 in its inhibition of ALK4, 5, and 7, and only weakly inhibits ALK1, 2, 3, and 6. A83-01 inhibits the TGFβ-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation 2 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2mg","offer_id":45980764831930,"sku":"04-0014","price":162.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":46329863700666,"sku":"04-0014-10","price":541.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-a83-01-p223-43_medium_735c5b36-a99e-4a18-b4bd-26401f69c80b.png?v=1781100694"},{"product_id":"stemolecule-alk5-inhibitor-repsox","title":"Stemolecule ALK5 Inhibitor (RepSox)","description":"\u003cp\u003eStemolecule ALK5 Inhibitor, also known as RepSox, E 616452, and SJN 2511, is a selective and ATP-competitive inhibitor of the TGFβ family type I receptor activin receptor-like kinase (ALK5) 1 . The ALK5 Inhibitor works by preventing autophosphorylation of ALK5. It has also been shown that ALK5 can replace Sox2 when reprogramming cells to induced pluripotent stem (iPS) cells. Through inhibition of the TGFβ pathway, ALK5 works to reprogram cells that have been transduced with Oct4, Klf4, and c-Myc 2 . ALK5 Inhibitor promotes the differentiation of MYH11-positive cells by modulating NOTCH signaling 4 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 mg","offer_id":45980764864698,"sku":"04-0015","price":143.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-alk5-inhibitor-repsox-p224-44_medium_51b67425-3629-478b-99e7-4686aa9e8b6b.png?v=1781100695"},{"product_id":"stemolecule-all-trans-retinoic-acid","title":"Stemolecule All-Trans Retinoic Acid","description":"\u003cp\u003eStemolecule All-Trans Retinoic Acid is the oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation and proliferation 1, 2 . It acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid × receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions activating gene transcription 3 . All-Trans Retinoic Acid has been implicated in specification of the embryonic anterior\/posterior axis through Hox gene regulation 4 . It has been used in various differentiation protocols, including B-cells, T-cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy 2,5-11 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"100 mg","offer_id":45980764897466,"sku":"04-0021","price":88.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-all-trans-retinoic-acid-p227-47_medium_c98b3e43-c8f0-437c-be1a-e53a43a2c6ff.png?v=1781100696"},{"product_id":"stemolecule-chir99021","title":"Stemolecule CHIR99021","description":"\u003cp\u003eThe aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3 β (GSK-3β) reported to date 1,2 . Unlike other potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs 3 . Along with the elimination of differentiation-inducing signaling from mitogen-activated protein kinases, using CHIR99021 to block the activity of GSK-3β enables the self-renewal of embryonic stem cells 4 . Also available as a convenient 10 mM solution in DMSO (Cat. No. 04-0004-02)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980764930234,"sku":"04-0004","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329887359162,"sku":"04-0004-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329887391930,"sku":"04-0004-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-chir99021-p213-33_medium_6b023944-3fbb-46e9-869b-f058b6e700c0.jpg?v=1781100698"},{"product_id":"stemolecule-cyclopamine","title":"Stemolecule Cyclopamine","description":"\u003cp\u003eStemolecule Cyclopamine is a steroid alkaloid isolated from the corn lily ( Veratrum californicum ) and originally identified as a teratogenic agent 1 . Cyclopamine has since been identified as a specific inhibitor of hedgehog signaling by direct binding to the heptahelical bundle of Smoothened 2 . Hedgehog signaling is involved in embryogenesis as well as cancer progression 3 . Cycoplamine has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells, as a modulator of cell proliferation, and as an anticancer drug 4- 6 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980764963002,"sku":"04-0022","price":162.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-cyclopamine-p228-48_medium_593a7a97-5e7d-4c56-98d1-327eceaee35a.png?v=1781100699"},{"product_id":"stemolecule-dapt","title":"Stemolecule DAPT","description":"\u003cp\u003eStemolecule DAPT (also known as GSI-IX or LY-374973), a cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate 1 . Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies 2 . DAPT has been shown to dose-dependently decrease amyloidβ levels via inhibition of γ-secretase in both plasma and cerebral spinal fluid 3 . Since amyloid β containing senile plaques are characteristic in Alzheimer's disease, DAPT may be useful in studies evaluating potential treatments for that disease.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980764995770,"sku":"04-0041","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-dapt-p240-59_medium_ffef63b9-7252-4d0f-850a-0ca4e8764953.png?v=1781100700"},{"product_id":"stemolecule-dorsomorphin","title":"Stemolecule Dorsomorphin","description":"\u003cp\u003eStemolecule Dorsomorphin dihydrochloride (also known as Compound C) is a potent inhibitor of AMP-activated protein kinase (AMPK) (K i =109nM) and bone morphogenic protein (BMP) signaling 1, 2 . It was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish 3 . Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1\/5\/8 phosphorylation 3 . BMP signaling coordinates developmental patterning and have essential physiological roles in mature organisms 4,5 . Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis, cardiomyogenesis and osteogenesis 3,6, 7 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765028538,"sku":"04-0024","price":156.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-dorsomorphin-p229-49_medium_83ba1786-5175-4529-ba93-c331c971934e.png?v=1781100702"},{"product_id":"stemolecule-doxycycline-hyclate","title":"Stemolecule Doxycycline hyclate","description":"\u003cp\u003eStemolecule Doxycycline hyclate (dox) is a broad spectrum antibiotic derivative of tetracycline and an inhibitor of matrix metalloproteinases 1 . Tetracycline-controlled transcriptional activation is a method of inducible expression whereby transcription is reversibly turned on or off in the presence of tetracycline or one of its derivatives such as dox 2 . For this type of reprogramming method, dox-inducible lentiviral reagents are used to induce the expression of virally transduced genes and generate induced pluripotent stem (iPS) cells from somatic cells 3-7 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 mg","offer_id":45980765094074,"sku":"04-0016","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-doxycycline-hyclate-p225-45_medium_83ca23cf-c996-4f17-961c-889ff87712c7.png?v=1781100703"},{"product_id":"stemolecule-forskolin","title":"Stemolecule Forskolin","description":"\u003cp\u003eStemolecule Forskolin is a natural compound produced by the Indian Coleus plant ( Coleus forskohlii ) 1 . It is used in several differentiation protocols for its ability to potentiate neuron differentiation 2,3 . Forskolin is able to stimulate adenylate cyclase activity and increases cyclic AMP 4 . Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes 5 . For example, cAMP can bind to protein kinase A (PKA) regulatory subunit and activate PKA which acts as a negative regulator of the hedgehog signaling pathway 6 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 mg","offer_id":45980765126842,"sku":"04-0025","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-forskolin-p230-50_medium_67222dcf-14dd-48b4-b9f7-b5b09ac0086c.png?v=1781100704"},{"product_id":"stemolecule-kaad-cyclopamine","title":"Stemolecule KAAD-Cyclopamine","description":"\u003cp\u003eStemolecule KAAD-Cyclopamine is a sonic hedgehog antagonist known to target Smoothened 1 . Hedgehog signaling is involved in embryogenesis as well as cancer progression 2 . KAAD-Cyclopamine has been utilized to halt the migration or proliferation of a variety of cancer cells (e.g., esophageal, gastrointestinal, hepatic and pancreatic cancer) 3-6 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"100 ug","offer_id":45980765159610,"sku":"04-0028","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-kaad-cyclopamine-p233-170_medium_1da1b283-2ce8-4896-a9c4-ff439810ac06.png?v=1781100706"},{"product_id":"stemolecule-ldn-193189","title":"Stemolecule LDN-193189","description":"\u003cp\u003eLDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC 50 = 5nM and 30nM respectively) 1 . LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation 1-3 . LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7 1 . BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms 4,5 . LDN-193189has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva 1 . Stemolecule LDN-193189 is a hydrochloride salt. Also available as a 10 mM stock solution (Cat. No. 04-0074-02) Discontinued Product Cat. No. 04-0019: Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluble in chloroform, this salt-based form is soluble in DMSO for your convenience.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765192378,"sku":"04-0074","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329909674170,"sku":"04-0074-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329909838010,"sku":"04-0074-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-ldn-193189-p248-67_medium_8f1bb700-ebc3-47f3-94d3-70346e2f949c.png?v=1781100707"},{"product_id":"stemolecule-pd0325901","title":"Stemolecule PD0325901","description":"\u003cp\u003ePD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK\/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK\/ERK and the inhibition of tumor cell proliferation 1,2 . Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells 3 . Also available as a 10 mM stock solution in DMSO (Cat. No. 04-0006-02)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765257914,"sku":"04-0006","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329899450554,"sku":"04-0006-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329908560058,"sku":"04-0006-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-pd0325901-p215-35_medium_eef6092c-3e4d-401c-9502-eb93f3281123.png?v=1781100708"},{"product_id":"stemolecule-purmorphamine","title":"Stemolecule Purmorphamine","description":"\u003cp\u003ePurmorphamine is a small molecule that promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts 1,2 . The mechanism of action study of Purmorphamine indicates that it is an agonist of Smoothened, a 7-transmembrane receptor of the hedgehog signaling pathway 3,4 . Purmorphamine can also be used to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells 5 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980765454522,"sku":"04-0009","price":143.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-purmorphamine-p218-38_medium_ea2565cb-aa11-48cb-97b1-cd6f5b9eeb87.png?v=1781100710"},{"product_id":"stemolecule-sb431542","title":"Stemolecule SB431542","description":"\u003cp\u003eSB431542 is an inhibitor of the transforming growth factor-β 1 (TGFβ1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGFβ signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -6 1,2 . SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells 3 . Also available: Stemolecule SB431542 in Solution (Cat, No. 04-0010-05)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980765487290,"sku":"04-0010","price":135.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329888014522,"sku":"04-0010-10","price":229.0,"currency_code":"USD","in_stock":true},{"title":"5mg (10mM)","offer_id":46329888506042,"sku":"04-0010-05","price":151.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-sb431542-p219-39_medium_781d00f0-0163-47d1-8018-d50535837b68.png?v=1781100713"},{"product_id":"stemolecule-sodium-butyrate","title":"Stemolecule Sodium Butyrate","description":"\u003cp\u003eSodium butyrate is the sodium salt of the short-chain fatty acid butyric acid. It is a metabolite of intestinal bacteria, a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract 1 . Sodium butyrate is also a known inhibitor of histone deacetylases (HDACs) 2 . HDAC inhibitors are promising anti-tumour agents that work by inhibiting cell proliferation and survival 3 . Along with the cytokines Activin A and acidic fibroblast growth factor (aFGF), sodium butyrate has been shown to direct the differentiation of mouse embryonic stem (ES) cells into hepatocytes 4 . Sodium butyrate has also been reported to increase the efficiency of transfection and expression for both transient and stable transfections 5 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"500 mg","offer_id":45980765520058,"sku":"04-0005","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-sodium-butyrate-p214-34_medium_af4226b4-1fd5-4ab3-9706-7274d7fdbee2.png?v=1781100715"},{"product_id":"stemolecule-thiazovivin","title":"Stemolecule Thiazovivin","description":"\u003cp\u003eThiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK) 1 . In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction 1 . This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGFβ receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold 2 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 mg","offer_id":45980765618362,"sku":"04-0017","price":285.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-thiazovivin-p226-46_medium_dde15acf-67f4-4727-96c8-87d6ff437888.png?v=1781100717"},{"product_id":"stemolecule-valproic-acid","title":"Stemolecule Valproic Acid","description":"\u003cp\u003eStemolecule Valproic Acid (VPA) is a cell-permeable, small molecule that has been shown to affect several pathways. VPA is a histone deacetylase (HDAC) inhibitor which improves reprogramming efficiency by at least 100 fold 1 . VPA also has been found to affect both the Extracellular Signal-Regulated Kinase (ERK), Protein Kinase C (PKC), and the Wnt\/β-Catenin pathways. VPA has been reported to regulate the differentiation and proliferation of various cells, including mesenchymal and hematopoietic stem cells, neuroblastoma cells, primary neurons and neural progenitor cells (NPCs) 2 . In the case of hepatic differentiation of mouse embryonic stem cells, Valproic Acid in combination with cytokines differentiate cells into a uniform and homogeneous cell population of hepatic progenitor cells followed by maturation into functional hepatocytes 3 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 g","offer_id":45980765651130,"sku":"04-0007","price":82.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-valproic-acid-p216-36_medium_ead79347-8ad0-42f6-8767-be30bafdc879.png?v=1781100719"},{"product_id":"stemolecule-wnt-inhibitor-iwp-2","title":"Stemolecule Wnt Inhibitor IWP-2","description":"\u003cp\u003eStemolecule Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt\/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin 1 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765782202,"sku":"04-0034","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-2-p237-56_medium_15bec70a-1559-4359-8d10-1674cea0e878.png?v=1781100722"},{"product_id":"stemolecule-wnt-inhibitor-iwp-3","title":"Stemolecule Wnt Inhibitor IWP-3","description":"\u003cp\u003eStemolecule Wnt Inhibitor IWP-3 was identified in a high throughput screen for antagonists of the Wnt\/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin 1 . The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the formation of cardiomyocytes from human embryonic stem cell-derived mesoderm cells 2 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765814970,"sku":"04-0035","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-3-p238-57_medium_2cbd47c7-d038-49fa-a0d8-7cc3101f9144.png?v=1781100723"},{"product_id":"stemolecule-wnt-inhibitor-iwp-4","title":"Stemolecule Wnt Inhibitor IWP-4","description":"\u003cp\u003eWnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt \/ β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin 1 . New 50 mg size now available.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765847738,"sku":"04-0036","price":135.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":46329916227770,"sku":"04-0036-50","price":1216.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-4-p239-58_medium_fca37da2-cbdb-4309-a1b7-e84c6f65a445.png?v=1781100724"},{"product_id":"stemolecule-xav939","title":"Stemolecule XAV939","description":"\u003cp\u003eStemolecule XAV939 is a cell-permeable small molecule inhibitor of the Wnt \/ β-catenin pathway. XAV939 inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation 1 . Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state 2 . 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This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors 3 . Y27632 in combination with Pifithrin-u significantly improves cell recovery after cryopreservation 4 . Stemolecule Y27632 is also available as a 10 mM DMSO Stock Solution (Cat. No. 04-0012-02). 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