{"title":"Stemolecule Small Molecules","description":null,"products":[{"product_id":"hes-cell-cloning-recovery-supplement","title":"hES Cell Cloning \u0026 Recovery Supplement","description":"\u003cp\u003eThe hES Cell Cloning and Recovery Supplement is a 1000X concentrate supplement that contains Thiazovivin at 2mM concentration. The hES Cell Cloning and Recovery Supplement can be used in several areas of cell culture to enhance productivity and efficiency. The addition of the hES Cell Cloning and Recovery Supplement to cell culture media significantly improves the likelihood of successful sub-cloning from single cells\u003csup\u003e1,2\u003c\/sup\u003e. This supplement was validated at a working concentration of 2 µM. However optimal conditions can vary and should be determined by the user. When added during a thaw, this supplement boosts recovery and thawing efficiency. The use of the hES Cell Cloning and Recovery Supplement also increases attachment after passaging. The hES Cell Cloning and Recovery Supplement is a valuable tool for escalating efficiency when working with human embryonic stem (hES) and human induced pluripotent stem (hiPS) cells under stressful conditions.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 x 100 μl","offer_id":45980764569786,"sku":"01-0014-500","price":208.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/hes-cell-cloning-recovery-supplement-p201-69_medium_6bf1447a-99b8-4155-bb8a-6f2c2d30655f.png?v=1781100692"},{"product_id":"stemolecule-a83-01","title":"Stemolecule A83-01","description":"\u003cp\u003eA83-01 is a selective inhibitor of the transforming growth factor-β (TGFβ) type I receptor ALK5, the Activin\/Nodal receptor ALK4, and the nodal receptor ALK7\u003csup\u003e1\u003c\/sup\u003e. This molecule is more potent than SB431542 in its inhibition of ALK4, 5, and 7, and only weakly inhibits ALK1, 2, 3, and 6. A83-01 inhibits the TGFβ-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation\u003csup\u003e2\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2mg","offer_id":45980764831930,"sku":"04-0014","price":162.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":46329863700666,"sku":"04-0014-10","price":541.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-a83-01-p223-43_medium_735c5b36-a99e-4a18-b4bd-26401f69c80b.png?v=1781100694"},{"product_id":"stemolecule-alk5-inhibitor-repsox","title":"Stemolecule ALK5 Inhibitor (RepSox)","description":"\u003cp\u003eStemolecule ALK5 Inhibitor, also known as RepSox, E 616452, and SJN 2511, is a selective and ATP-competitive inhibitor of the TGFβ family type I receptor activin receptor-like kinase (ALK5)\u003csup\u003e1\u003c\/sup\u003e. The ALK5 Inhibitor works by preventing autophosphorylation of ALK5. It has also been shown that ALK5 can replace Sox2 when reprogramming cells to induced pluripotent stem (iPS) cells. Through inhibition of the TGFβ pathway, ALK5 works to reprogram cells that have been transduced with Oct4, Klf4, and c-Myc\u003csup\u003e2\u003c\/sup\u003e. ALK5 Inhibitor promotes the differentiation of MYH11-positive cells by modulating NOTCH signaling\u003csup\u003e4\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 mg","offer_id":45980764864698,"sku":"04-0015","price":143.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-alk5-inhibitor-repsox-p224-44_medium_51b67425-3629-478b-99e7-4686aa9e8b6b.png?v=1781100695"},{"product_id":"stemolecule-all-trans-retinoic-acid","title":"Stemolecule All-Trans Retinoic Acid","description":"\u003cp\u003eStemolecule All-Trans Retinoic Acid is the oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation and proliferation\u003csup\u003e1, 2\u003c\/sup\u003e. It acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid × receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions, activating gene transcription\u003csup\u003e3\u003c\/sup\u003e. All-Trans Retinoic Acid has been implicated in specification of the embryonic anterior\/posterior axis through Hox gene regulation\u003csup\u003e4\u003c\/sup\u003e. It has been used in various differentiation protocols, including B-cells, T-cells, and neurons, and applied clinically to treat cancer as a form of differentiation-induction therapy\u003csup\u003e2,5-11\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"100 mg","offer_id":45980764897466,"sku":"04-0021","price":88.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-all-trans-retinoic-acid-p227-47_medium_c98b3e43-c8f0-437c-be1a-e53a43a2c6ff.png?v=1781100696"},{"product_id":"stemolecule-chir99021","title":"Stemolecule CHIR99021","description":"\u003cp\u003eThe aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β (GSK-3β) reported to date\u003csup\u003e1,2\u003c\/sup\u003e. Unlike other potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs\u003csup\u003e3\u003c\/sup\u003e. Along with the elimination of differentiation-inducing signaling from mitogen-activated protein kinases, using CHIR99021 to block the activity of GSK-3β enables the self-renewal of embryonic stem cells\u003csup\u003e4\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eAlso available as a convenient 10 mM solution in DMSO (Cat. No. 04-0004-02)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980764930234,"sku":"04-0004","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329887359162,"sku":"04-0004-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329887391930,"sku":"04-0004-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-chir99021-p213-33_medium_6b023944-3fbb-46e9-869b-f058b6e700c0.jpg?v=1781100698"},{"product_id":"stemolecule-cyclopamine","title":"Stemolecule Cyclopamine","description":"\u003cp\u003eStemolecule Cyclopamine is a steroid alkaloid isolated from the corn lily (\u003cem\u003eVeratrum californicum\u003c\/em\u003e) and originally identified as a teratogenic agent\u003csup\u003e1\u003c\/sup\u003e. Cyclopamine has since been identified as a specific inhibitor of hedgehog signaling by direct binding to the heptahelical bundle of Smoothened\u003csup\u003e2\u003c\/sup\u003e. Hedgehog signaling is involved in embryogenesis as well as cancer progression\u003csup\u003e3\u003c\/sup\u003e. Cycoplamine has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells, as a modulator of cell proliferation, and as an anticancer drug\u003csup\u003e4-6\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980764963002,"sku":"04-0022","price":162.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-cyclopamine-p228-48_medium_593a7a97-5e7d-4c56-98d1-327eceaee35a.png?v=1781100699"},{"product_id":"stemolecule-dapt","title":"Stemolecule DAPT","description":"\u003cp\u003eStemolecule DAPT (also known as GSI-IX or LY-374973), a cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate\u003csup\u003e1\u003c\/sup\u003e. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies\u003csup\u003e2\u003c\/sup\u003e DAPT has been shown to dose-dependently decrease amyloidβ levels via inhibition of γ-secretase in both plasma and cerebrospinal fluid\u003csup\u003e3\u003c\/sup\u003e. Since amyloid β-containing senile plaques are characteristic in Alzheimer's disease, DAPT may be useful in studies evaluating potential treatments for that disease.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980764995770,"sku":"04-0041","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-dapt-p240-59_medium_ffef63b9-7252-4d0f-850a-0ca4e8764953.png?v=1781100700"},{"product_id":"stemolecule-dorsomorphin","title":"Stemolecule Dorsomorphin","description":"\u003cp\u003eStemolecule Dorsomorphin dihydrochloride (also known as Compound C) is a potent inhibitor of AMP-activated protein kinase (AMPK) (K\u003csub\u003ei\u003c\/sub\u003e=10\u003csup\u003e-9\u003c\/sup\u003e nM) and bone morphogenic protein (BMP) signaling\u003csup\u003e1,2\u003c\/sup\u003e. It was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafis\u003csup\u003e3\u003c\/sup\u003e. Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1\/5\/8 phosphorylation\u003csup\u003e3\u003c\/sup\u003e. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms\u003csup\u003e4,5\u003c\/sup\u003e. Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis, cardiomyogenesis, and osteogenesis\u003csup\u003e3,6,7\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765028538,"sku":"04-0024","price":156.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-dorsomorphin-p229-49_medium_83ba1786-5175-4529-ba93-c331c971934e.png?v=1781100702"},{"product_id":"stemolecule-doxycycline-hyclate","title":"Stemolecule Doxycycline hyclate","description":"\u003cp\u003eStemolecule Doxycycline hyclate (dox) is a broad-spectrum antibiotic derivative of tetracycline and an inhibitor of matrix metalloproteinases\u003csup\u003e1\u003c\/sup\u003e. Tetracycline-controlled transcriptional activation is a method of inducible expression whereby transcription is reversibly turned on or off in the presence of tetracycline or one of its derivatives, such as dox\u003csup\u003e2\u003c\/sup\u003e. For this type of reprogramming method, dox-inducible lentiviral reagents are used to induce the expression of virally transduced genes and generate induced pluripotent stem (iPS) cells from somatic cells\u003csup\u003e3-7\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThis product is intended for Research Use Only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 mg","offer_id":45980765094074,"sku":"04-0016","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-doxycycline-hyclate-p225-45_medium_83ca23cf-c996-4f17-961c-889ff87712c7.png?v=1781100703"},{"product_id":"stemolecule-forskolin","title":"Stemolecule Forskolin","description":"\u003cp\u003eStemolecule Forskolin is a natural compound produced by the Indian Coleus plant (\u003cem\u003eColeus forskohlii\u003c\/em\u003e)\u003csup\u003e1\u003c\/sup\u003e. It is used in several differentiation protocols for its ability to potentiate neuron differentiation\u003csup\u003e2,3\u003c\/sup\u003e. Forskolin can stimulate adenylate cyclase activity and increase cyclic AMP\u003csup\u003e4\u003c\/sup\u003e. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes\u003csup\u003e5\u003c\/sup\u003e. For example, cAMP can bind to protein kinase A (PKA) regulatory subunit and activate PKA which acts as a negative regulator of the hedgehog signaling pathway\u003csup\u003e6\u003c\/sup\u003e\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 mg","offer_id":45980765126842,"sku":"04-0025","price":199.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-forskolin-p230-50_medium_67222dcf-14dd-48b4-b9f7-b5b09ac0086c.png?v=1781100704"},{"product_id":"stemolecule-kaad-cyclopamine","title":"Stemolecule KAAD-Cyclopamine","description":"\u003cp\u003eStemolecule KAAD-Cyclopamine is a sonic hedgehog antagonist known to target Smoothened\u003csup\u003e1\u003c\/sup\u003e. Hedgehog signaling is involved in embryogenesis as well as cancer progression\u003csup\u003e2\u003c\/sup\u003e. KAAD-Cyclopamine has been utilized to halt the migration or proliferation of a variety of cancer cells (e.g., esophageal, gastrointestinal, hepatic, and pancreatic cancer)\u003csup\u003e3-6\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"100 ug","offer_id":45980765159610,"sku":"04-0028","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-kaad-cyclopamine-p233-170_medium_1da1b283-2ce8-4896-a9c4-ff439810ac06.png?v=1781100706"},{"product_id":"stemolecule-ldn-193189","title":"Stemolecule LDN-193189","description":"\u003cp\u003eLDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC 50 = 5 nM and 30 nM, respectively)\u003csup\u003e1\u003c\/sup\u003e. LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation\u003csup\u003e1-3\u003c\/sup\u003e. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7\u003csup\u003e1\u003c\/sup\u003e. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms \u003csup\u003e4,5\u003c\/sup\u003e. LDN-19318 9has been used to reduce ectopic ossification in a mouse model of \u003cem\u003efibrodysplasia ossificans progressiva\u003c\/em\u003e\u003csup\u003e1\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eStemolecule LDN-193189 is a hydrochloride salt. Also available as a 10 mM stock solution (Cat. No. 04-0074-02) \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDiscontinued Product Cat. No. 04-0019\u003c\/strong\u003e: Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluble in chloroform, this salt-based form is soluble in DMSO for your convenience.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765192378,"sku":"04-0074","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329909674170,"sku":"04-0074-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329909838010,"sku":"04-0074-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-ldn-193189-p248-67_medium_8f1bb700-ebc3-47f3-94d3-70346e2f949c.png?v=1781100707"},{"product_id":"stemolecule-pd0325901","title":"Stemolecule PD0325901","description":"\u003cp\u003ePD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK\/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK\/ERK and the inhibition of tumor cell proliferation\u003csup\u003e1,2\u003c\/sup\u003e. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eAlso available as a 10 mM stock solution in DMSO (Cat. No. 04-0006-02)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765257914,"sku":"04-0006","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329899450554,"sku":"04-0006-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329908560058,"sku":"04-0006-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-pd0325901-p215-35_medium_eef6092c-3e4d-401c-9502-eb93f3281123.png?v=1781100708"},{"product_id":"stemolecule-purmorphamine","title":"Stemolecule Purmorphamine","description":"\u003cp\u003ePurmorphamine is a small molecule that promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts\u003csup\u003e1,2\u003c\/sup\u003e. The mechanism of action study of Purmorphamine indicates that it is an agonist of Smoothened, a 7-transmembrane receptor of the hedgehog signaling pathway\u003csup\u003e3,4\u003c\/sup\u003e. Purmorphamine can also be used to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells\u003csup\u003e5\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980765454522,"sku":"04-0009","price":143.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-purmorphamine-p218-38_medium_ea2565cb-aa11-48cb-97b1-cd6f5b9eeb87.png?v=1781100710"},{"product_id":"stemolecule-sb431542","title":"Stemolecule SB431542","description":"\u003cp\u003eSB431542 is an inhibitor of the transforming growth factor-β1 (TGFβ1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5, and -7. SB431542 inhibits endogenous activin and TGFβ signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -6\u003csup\u003e1,2\u003c\/sup\u003e. SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eAlso available: Stemolecule SB431542 in Solution (Cat, No. 04-0010-05)\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 mg","offer_id":45980765487290,"sku":"04-0010","price":135.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329888014522,"sku":"04-0010-10","price":229.0,"currency_code":"USD","in_stock":true},{"title":"5mg (10mM)","offer_id":46329888506042,"sku":"04-0010-05","price":151.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-sb431542-p219-39_medium_781d00f0-0163-47d1-8018-d50535837b68.png?v=1781100713"},{"product_id":"stemolecule-sodium-butyrate","title":"Stemolecule Sodium Butyrate","description":"\u003cp\u003eSodium butyrate is the sodium salt of the short-chain fatty acid butyric acid. It is a metabolite of intestinal bacteria, a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract\u003csup\u003e1\u003c\/sup\u003e. Sodium butyrate is also a known inhibitor of histone deacetylases (HDACs)\u003csup\u003e2\u003c\/sup\u003e. HDAC inhibitors are promising anti-tumour agents that work by inhibiting cell proliferation and survival\u003csup\u003e3\u003c\/sup\u003e. Along with the cytokines Activin A and acidic fibroblast growth factor (aFGF), sodium butyrate has been shown to direct the differentiation of mouse embryonic stem (ES) cells into hepatocytes\u003csup\u003e4\u003c\/sup\u003e. Sodium butyrate has also been reported to increase the efficiency of transfection and expression for both transient and stable transfections\u003csup\u003e5\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"500 mg","offer_id":45980765520058,"sku":"04-0005","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-sodium-butyrate-p214-34_medium_af4226b4-1fd5-4ab3-9706-7274d7fdbee2.png?v=1781100715"},{"product_id":"stemolecule-thiazovivin","title":"Stemolecule Thiazovivin","description":"\u003cp\u003eThiazovivin is a selective, cell-permeable small molecule that directly targets Rho-associated kinase (ROCK)\u003csup\u003e1\u003c\/sup\u003e. In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin-mediated cell-cell interaction\u003csup\u003e1\u003c\/sup\u003e. This observation suggests that Thiazovivin promotes cell survival. In other studies, Thiazovivin, in combination with inhibitors of the TGFβ receptor and MEK pathway, has been shown to improve reprogramming efficiency by more than 200-fold\u003csup\u003e2\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"1 mg","offer_id":45980765618362,"sku":"04-0017","price":285.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-thiazovivin-p226-46_medium_dde15acf-67f4-4727-96c8-87d6ff437888.png?v=1781100717"},{"product_id":"stemolecule-valproic-acid","title":"Stemolecule Valproic Acid","description":"\u003cp\u003eStemolecule Valproic Acid (VPA) is a cell-permeable small molecule that has been shown to affect several pathways. VPA is a histone deacetylase (HDAC) inhibitor that improves reprogramming efficiency by at least 100-fold\u003csup\u003e1\u003c\/sup\u003e. VPA also has been found to affect the Extracellular Signal-Regulated Kinase (ERK), Protein Kinase C (PKC), and the Wnt\/β-Catenin pathways. VPA has been reported to regulate the differentiation and proliferation of various cells, including mesenchymal and hematopoietic stem cells, neuroblastoma cells, primary neurons, and neural progenitor cells (NPCs)\u003csup\u003e2\u003c\/sup\u003e. In the case of hepatic differentiation of mouse embryonic stem cells, Valproic Acid in combination with cytokines differentiates cells into a uniform and homogeneous cell population of hepatic progenitor cells followed by maturation into functional hepatocytes\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"5 g","offer_id":45980765651130,"sku":"04-0007","price":82.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-valproic-acid-p216-36_medium_ead79347-8ad0-42f6-8767-be30bafdc879.png?v=1781100719"},{"product_id":"stemolecule-wnt-inhibitor-iwp-2","title":"Stemolecule Wnt Inhibitor IWP-2","description":"\u003cp\u003eStemolecule Wnt Inhibitor IWP-2 was identified in a high-throughput screen for antagonists of the Wnt\/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitoylation of Wnt proteins by Porcupine (Porcn), a membrane-bound \u003cem\u003eO\u003c\/em\u003e-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and the accumulation of both Dvl2 and β-catenin\u003csup\u003e1\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765782202,"sku":"04-0034","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-2-p237-56_medium_15bec70a-1559-4359-8d10-1674cea0e878.png?v=1781100722"},{"product_id":"stemolecule-wnt-inhibitor-iwp-3","title":"Stemolecule Wnt Inhibitor IWP-3","description":"\u003cp\u003eStemolecule Wnt Inhibitor IWP-3 was identified in a high-throughput screen for antagonists of the Wnt\/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitoylation of Wnt proteins by Porcupine (Porcn), a membrane-bound \u003cem\u003eO\u003c\/em\u003e-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin\u003csup\u003e1\u003c\/sup\u003e. The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the formation of cardiomyocytes from human embryonic stem cell-derived mesoderm cells\u003csup\u003e1\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765814970,"sku":"04-0035","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-3-p238-57_medium_2cbd47c7-d038-49fa-a0d8-7cc3101f9144.png?v=1781100723"},{"product_id":"stemolecule-wnt-inhibitor-iwp-4","title":"Stemolecule Wnt Inhibitor IWP-4","description":"\u003cp\u003eWnt Inhibitor IWP-4 was identified in a high-throughput screen for antagonists of the Wnt \/ β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitoylation of Wnt proteins by Porcupine (Porcn), a membrane-bound \u003cem\u003eO\u003c\/em\u003e-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin\u003csup\u003e1\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNew 50 mg size now available.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765847738,"sku":"04-0036","price":135.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":46329916227770,"sku":"04-0036-50","price":1216.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-4-p239-58_medium_fca37da2-cbdb-4309-a1b7-e84c6f65a445.png?v=1781100724"},{"product_id":"stemolecule-xav939","title":"Stemolecule XAV939","description":"\u003cp\u003eStemolecule XAV939 is a cell-permeable small molecule inhibitor of the Wnt \/ β-catenin pathway. XAV939 inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation\u003csup\u003e1\u003c\/sup\u003e. Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state\u003csup\u003e2\u003c\/sup\u003e. Wnt proteins act on a variety of stem cells that include neural, mammary, and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line\u003csup\u003e1\u003c\/sup\u003e.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980766077114,"sku":"04-0046","price":270.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-xav939-p241-60_medium_53b7f5c5-237d-4bb3-8189-cb93204818cc.png?v=1781100726"},{"product_id":"stemolecule-y27632","title":"Stemolecule Y27632","description":"\u003cp\u003eY27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor\u003csup\u003e1\u003c\/sup\u003e. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency\u003csup\u003e2\u003c\/sup\u003e. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors\u003csup\u003e3\u003c\/sup\u003e. Y27632 in combination with Pifithrin-u significantly improves cell recovery after cryopreservation\u003csup\u003e4\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eStemolecule Y27632 is also available as a 10 mM DMSO Stock Solution (Cat. No. 04-0012-02).\u003c\/p\u003e\n\u003cp\u003eY27632 is widely used in naive stem cell protocols\u003csup\u003e5\u003c\/sup\u003e, such as the 5i\/L\/A\/ protocol.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980766109882,"sku":"04-0012","price":172.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329867305146,"sku":"04-0012-10","price":675.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329883787450,"sku":"04-0012-02","price":191.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-y27632-p221-41_medium_3c401b79-598c-4d0f-bb0f-f065e7ee0dd7.png?v=1781100727"}],"url":"https:\/\/store.reprocell.com\/collections\/stemolecule-small-molecules.oembed","provider":"Reprocell","version":"1.0","type":"link"}