{"product_id":"imatrix-411-endothelial-cell-substrate","title":"iMatrix-411 Endothelial Cell Substrate","description":"\u003ch2\u003eHigh purity, recombinant human Laminin-411 E8 Fragment expressed in CHO-S cells. \u003c\/h2\u003e\n\u003cp\u003eLaminin-411 is found predominantly in the vascular endothelial basement membrane. Stem cells cultivated on iMatrix-411 are robustly induced to differentiate into endothelial progenitor cells.\u003c\/p\u003e\n\u003cp\u003eiMatrix-411 features make it an ideal matrix for some cell culture applications:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eXeno-free formulation \/ CHO-S cell bioproduction\u003c\/li\u003e\n\u003cli\u003eEasy to use (liquid format)\u003c\/li\u003e\n\u003cli\u003eE8-fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-411\u003c\/li\u003e\n\u003cli\u003eCultivation of iPSC on iMatrix-411 induces a cell fate transition to endothelial progenitor cells\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eiMatrix-411 is a highly purified and refined product of human recombinant laminin-411 (E8 fragment) expressed by CHO-S cells. Laminin-411 is found predominantly expressed in the vascular endothelial basement membrane\u003csup\u003e1\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eand in Langerhans islet capillary endothelial cells of the pancreas.\u003csup\u003e2\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eAs a cell culture ECM substrate, iMatrix-411 can assist in establishing human endothelial cell primary cultures from fresh human bio-specimens.\u003c\/p\u003e\n\u003cp\u003eHuman iPS cells, when cultured on iMatrix-411, are robustly induced (\u0026gt;95%) to differentiate into endothelial progenitor cells with angiogenesis capacity.\u003csup\u003e1\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eOther published reports have used iMatrix-411 and iMatrix-511 in a step-wise protocol to generate cholangiocytes capable of forming 3D cyst-structures from iPSC-derived hepatoblastic cells.\u003csup\u003e3\u003c\/sup\u003e\u003c\/p\u003e","brand":"Matrixome","offers":[{"title":"175 μg × 2 tubes","offer_id":50533177491642,"sku":"NP892-041","price":509.0,"currency_code":"USD","in_stock":true},{"title":"175 μg × 6 tubes","offer_id":50533177524410,"sku":"NP892-042","price":1418.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/iMatrix-411Pict.png?v=1790347743","url":"https:\/\/store.reprocell.com\/products\/imatrix-411-endothelial-cell-substrate","provider":"Reprocell","version":"1.0","type":"link"}