iMatrix 511-SILK Stem Cell Culture Substrate

Recombinant Laminin-511 E8-Fragments, expressed in Silkworm iMatrix-511 SILK is a highly purified and refined laminin-511 E8 fragments, produced in Silkworms. iMatrix-511 SILK features make it an ideal matrix for pluripotent stem cell culture: Promotes greater stem cell adhesion than all other matrix proteins that have been tested Easy to use (liquid format) E8 fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-511 Equivalent performance, but lower cost than the legacy iMatrix-511 product Laminin is localized to the basement membrane and plays a key role in cell adhesion and proliferation. Laminin-511 (α5, β1 laminin) binds to integrin α6β1 to promote cell signaling. Laminin-511 provides an ideal matrix for the proliferation of a wide variety of cell types including stem and iPS cells. iMatrix-511 SILK  is functionally equivalent to iMatrix-511 ( Cat. No. NP892-011 ). The only difference is the expression system used for bioproduction. The iMatrix-511 SILK product is produced in recombinant silkworm cocoon, while iMatrix-511 is produced in CHO-S cells. Both are E8 fragments that have been purified using the same processes.