{"product_id":"stemedit-imsc-b2m-ciita-dko-repromsc14-1","title":"StemEdit iMSC B2M\/CIITA DKO ReproMSC14","description":"\u003ch2\u003e\u003cstrong\u003eHypoimmune Human iPSC-derived MSCs with B2M and CIITA Double Knockout \u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eRepro MSC14 are ready-to-use iPSC-derived mesenchymal stem cells (iMSCs) generated from \u003ca href=\"https:\/\/www.reprocell.com\/stemedit-gene-edited-ipscs\/stemedit-human-ipsc-b2m-ciita-dko-llf-34\" rel=\"noopener\"\u003eStemEdit hiPSC B2M\/CIITA DKO\u003c\/a\u003e (Cat. No. RCRP052), a gene-edited version of one of our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.reprocell.com\/clinical-stem-cell-services\/gmp-ipsc-production\"\u003eStemRNA™ Clinical Lines\u003c\/a\u003e, RPC-LLF-34-F3.  The analogous wild-type iMSCs line (\u003ca href=\"https:\/\/store.reprocell.com\/products\/repro-msc10-ipsc-derived-mscs-phenol-red-free\"\u003eRepro MSC10 iPSC-derived MSCs (iMSCs), Phenol Red-Free, Cat. No. RCRP038\u003c\/a\u003e) is also available.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReproMSC14 cells do not contain Phenol Red\u003c\/strong\u003e, making them ideal for exosome research.\u003c\/p\u003e\n\u003cp\u003eiPSC-derived MSCs, sometimes called iMSCs, offer several advantages over primary MSCs, including a renewable cell source, enhanced scalability, greater batch-to-batch consistency, high proliferative capacity, and suitability for genetic engineering. Find out more about their potential therapeutic advantages in our recent blog post \"\u003ca href=\"https:\/\/www.reprocell.com\/blog\/the-therapeutic-advantage-of-induced-pluripotent-stem-cells-derived-mesenchymal-stem-cells-imscs\"\u003eThe Therapeutic Advantage of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells (iMSCs)\u003c\/a\u003e\".\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReproMSC14 cells feature:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEasy access to hypoimmune MSCs from a reproducible source.\u003c\/li\u003e\n\u003cli\u003eImmediate thawing into Phenol Red-free MSC NutriStem XF Culture medium (Cat. No.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/store.reprocell.com\/products\/msc-nutristem-xf-medium-phenol-red-free\"\u003e01-0007\u003c\/a\u003e) on vitronectin or NutriCoat™ Attachment Solution (Cat. No.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/store.reprocell.com\/products\/nutricoat-attachment-solution\"\u003e05-0063\u003c\/a\u003e) with easy conversion to other standard MSC Media.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eNOTE:\u003c\/strong\u003e  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThese iMSC cell lines are developed and supplied for \u003cstrong\u003eResearch Use Only (RUO)\u003c\/strong\u003e. They are \u003cstrong\u003enot intended for clinical or therapeutic applications\u003c\/strong\u003e. However, the iPSC clone from which these iMSCs were derived has a \u003cstrong\u003eclinical-grade iPSC counterpart\u003c\/strong\u003e that is suitable for clinical gene editing and downstream clinical development. If you require material for translational or clinical programs, please \u003cspan\u003esee \u003c\/span\u003e\u003ca href=\"https:\/\/www.reprocell.com\/clinical-stem-cell-services\"\u003e\u003cspan\u003eClinical Stem Cell Services\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or \u003c\/span\u003e\u003ca href=\"https:\/\/www.reprocell.com\/contact\"\u003e\u003cspan\u003eContact Us\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSee also our complete collections of Research Use Only \u003c\/span\u003e\u003ca href=\"https:\/\/www.reprocell.com\/product-catalog\/mesenchymal-stem-cells\" rel=\"noopener\"\u003eReproMSC iPSC-derived MSCs (iMSCs)\u003c\/a\u003e\u003cspan\u003e and \u003ca href=\"https:\/\/www.reprocell.com\/product-catalog\/stemedit-gene-edited-ipscs\" rel=\"noopener\"\u003eStemEdit Gene-Edited iPSC Lines\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable height=\"256\" style=\"border-collapse: collapse; table-layout: fixed; margin-left: auto; margin-right: auto; border: 1px solid #99acc2; width: 84.0164%; height: 371.953px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eCat. No.:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eRCRP057\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 43.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 43.7969px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #EEEEEE; padding: 4px; width: 49.933%; height: 43.7969px; border-color: #CCCCCC;\" width=\"312\"\u003eB2M\/CIITA double knockout\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 36.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; padding-top: 4px; padding-right: 4px; padding-bottom: 4px; height: 36.7969px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eMutation validation:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; padding: 4px; border: 1px solid #EEEEEE; height: 36.7969px; border-color: #CCCCCC;\"\u003e\n\u003cp\u003eDNA Sequencing, B2M expression (flow) \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 40.5938px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 40.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eParent Clone ID:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 40.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\" width=\"312\"\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.reprocell.com\/stemedit-gene-edited-ipscs\/stemedit-human-ipsc-b2m-ciita-dko-llf-34\" rel=\"noopener\"\u003eStemEdit hiPSC B2M\/CIITA DKO\u003c\/a\u003e (Cat. No. RCRP052), which were derived from StemRNA Clinical iPSC Clone LLF-34-F3\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 36.5938px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 36.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eDonor Blood Type:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 36.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\" width=\"312\"\u003e\n\u003cp\u003eO positive\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eDonor Race:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eCaucasian\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eDonor Sex:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eFemale\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eDonor Age:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e22\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eReprogramming Technology:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eStemRNA Clinical Reprogramming Technology\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eTissue Source:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eSkin (Fibroblasts)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.7969px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eKaryotype:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 23.7969px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eNormal (46 XX)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 47.5938px;\"\u003e\n\u003ctd style=\"width: 49.933%; height: 47.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003e\u003cstrong\u003eMicrobiology:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 49.933%; height: 47.5938px; padding: 4px; border: 1px solid #EEEEEE; border-color: #CCCCCC;\"\u003eNegative for bacteria, virus, and mycoplasma\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Reprocell","offers":[{"title":"1 vial (1 million cells)","offer_id":50853688967354,"sku":"RCRP057","price":1900.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/Vial_MSC14_1.jpg?v=1793115509","url":"https:\/\/store.reprocell.com\/products\/stemedit-imsc-b2m-ciita-dko-repromsc14-1","provider":"Reprocell","version":"1.0","type":"link"}