{"product_id":"stemfactor-bmp-4-human-recombinant","title":"Stemfactor BMP-4, Human Recombinant","description":"\u003cp\u003eBone Morphogenetic Protein 4 (BMP-4) is a polypeptide belonging to the TGFβ protein super-family. BMP-4 is involved in bone and cartilage development; more specifically, in tooth and limb development fracture repair 1 . In human embryonic development, BMP-4 is a critical signaling molecule required for the early differentiation of the embryo and establishment of a dorsal-ventral axis 2,3 . BMP-4 plays an important role in the differentiation of overlying ectodermal tissue. Inhibition of the BMP-4 signal causes the ectoderm to differentiate into the neural plate. In cultured stem cells, BMP-4 plays a distinct role in mouse and human embryonic stem (ES) cells. BMP-4 supports LIF as a positive factor for mouse ES cell self-renewal 4 . In contrast, BMP-4 induces extra-embryonic trophoblast differentiation in human pluripotent stem cells 5 . Stemfactor BMP-4 is a recombinant protein expressed and purified from human 293 cells as a glycosylated homodimer with a molecular mass of 34 kDa.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"10 μg","offer_id":45980762603706,"sku":"03-0007","price":297.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemfactor-bmp-4-human-recombinant-p205-164_medium_4dcf4385-43ea-4159-8b10-90a84275de36.jpg?v=1781100650","url":"https:\/\/store.reprocell.com\/products\/stemfactor-bmp-4-human-recombinant","provider":"Reprocell","version":"1.0","type":"link"}