Stemgent
Stemolecule CHIR99021
| QTY | Cat # | Size | Unit Price |
|---|---|---|---|
|
|
04-0004 | 2 mg | $276.00 |
|
|
04-0004-10 | 10 mg | $1,081.00 |
|
|
04-0004-02 | 2mg (10mM) | $324.00 |
* Prices listed are in USD. Taxes, shipping & handling not included. Contact us for bulk pricing.
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Overview
The aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3 β (GSK-3β) reported to date 1,2 . Unlike other potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs 3 . Along with the elimination of differentiation-inducing signaling from mitogen-activated protein kinases, using CHIR99021 to block the activity of GSK-3β enables the self-renewal of embryonic stem cells 4 . Also available as a convenient 10 mM solution in DMSO (Cat. No. 04-0004-02)