Stemolecule DAPT

Stemolecule DAPT (also known as GSI-IX or LY-374973), a cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate 1 . Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies 2 . DAPT has been shown to dose-dependently decrease amyloidβ levels via inhibition of γ-secretase in both plasma and cerebral spinal fluid 3 . Since amyloid β containing senile plaques are characteristic in Alzheimer's disease, DAPT may be useful in studies evaluating potential treatments for that disease.