{"product_id":"stemolecule-dorsomorphin","title":"Stemolecule Dorsomorphin","description":"\u003cp\u003eStemolecule Dorsomorphin dihydrochloride (also known as Compound C) is a potent inhibitor of AMP-activated protein kinase (AMPK) (K i =109nM) and bone morphogenic protein (BMP) signaling 1, 2 . It was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish 3 . Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1\/5\/8 phosphorylation 3 . BMP signaling coordinates developmental patterning and have essential physiological roles in mature organisms 4,5 . Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis, cardiomyogenesis and osteogenesis 3,6, 7 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765028538,"sku":"04-0024","price":156.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-dorsomorphin-p229-49_medium_83ba1786-5175-4529-ba93-c331c971934e.png?v=1781100702","url":"https:\/\/store.reprocell.com\/products\/stemolecule-dorsomorphin","provider":"Reprocell","version":"1.0","type":"link"}