Stemolecule LDN-193189

LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC 50 = 5nM and 30nM respectively) 1 . LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation 1-3 . LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7 1 . BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms 4,5 . LDN-193189has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva 1 . Stemolecule LDN-193189 is a hydrochloride salt. Also available as a 10 mM stock solution (Cat. No. 04-0074-02) Discontinued Product Cat. No. 04-0019: Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluble in chloroform, this salt-based form is soluble in DMSO for your convenience.