{"product_id":"stemolecule-ldn-193189","title":"Stemolecule LDN-193189","description":"\u003cp\u003eLDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC 50 = 5nM and 30nM respectively) 1 . LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation 1-3 . LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7 1 . BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms 4,5 . LDN-193189has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva 1 . Stemolecule LDN-193189 is a hydrochloride salt. Also available as a 10 mM stock solution (Cat. No. 04-0074-02) Discontinued Product Cat. No. 04-0019: Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluble in chloroform, this salt-based form is soluble in DMSO for your convenience.\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765192378,"sku":"04-0074","price":276.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":46329909674170,"sku":"04-0074-10","price":1081.0,"currency_code":"USD","in_stock":true},{"title":"2mg (10mM)","offer_id":46329909838010,"sku":"04-0074-02","price":324.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-ldn-193189-p248-67_medium_8f1bb700-ebc3-47f3-94d3-70346e2f949c.png?v=1781100707","url":"https:\/\/store.reprocell.com\/products\/stemolecule-ldn-193189","provider":"Reprocell","version":"1.0","type":"link"}