Stemgent
Stemolecule Wnt Inhibitor IWP-2
| QTY | Cat # | Size | Unit Price |
|---|---|---|---|
|
|
04-0034 | 2 mg | $135.00 |
* Prices listed are in USD. Taxes, shipping & handling not included. Contact us for bulk pricing.
Have questions?
Overview
Stemolecule Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin 1 .