{"product_id":"stemolecule-wnt-inhibitor-iwp-3","title":"Stemolecule Wnt Inhibitor IWP-3","description":"\u003cp\u003eStemolecule Wnt Inhibitor IWP-3 was identified in a high throughput screen for antagonists of the Wnt\/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin 1 . The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the formation of cardiomyocytes from human embryonic stem cell-derived mesoderm cells 2 .\u003c\/p\u003e","brand":"Stemgent","offers":[{"title":"2 mg","offer_id":45980765814970,"sku":"04-0035","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0764\/3119\/6346\/files\/stemolecule-wnt-inhibitor-iwp-3-p238-57_medium_2cbd47c7-d038-49fa-a0d8-7cc3101f9144.png?v=1781100723","url":"https:\/\/store.reprocell.com\/products\/stemolecule-wnt-inhibitor-iwp-3","provider":"Reprocell","version":"1.0","type":"link"}