Stemgent
Stemolecule XAV939
| QTY | Cat # | Size | Unit Price |
|---|---|---|---|
|
|
04-0046 | 2 mg | $270.00 |
* Prices listed are in USD. Taxes, shipping & handling not included. Contact us for bulk pricing.
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Overview
Stemolecule XAV939 is a cell-permeable small molecule inhibitor of the Wnt / β-catenin pathway. XAV939 inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation 1 . Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state 2 . Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line 1 .