Stemgent Stemolecule PD0325901

Code: 04-0006-base
  • $235.00
  • (Delivery from $95.00 )
Available   |   Usually dispatched within 24 hours
Prices apply to customers in North America only
Be the first to review Stemolecule PD0325901. Write a review

PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells3.

Also available as a 10 mM stock solution in DMSO (Cat. No. 04-0006-02)


Product Name

Stemolecule PD0325901

Catalog Number



2 mg (Cat. No. 04-0006)

10 mg (Cat. No. 04-0006-10)

2 mg in 10 mM DMSO (Cat. No. 04-0006-02)

Alternate Name(s)


Chemical Formula


Molecular Weight


CAS Number



Greater than 95% by HPLC analysis


Pale purple solid


Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability

Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control

The purity of PD0325901 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM — 100µm of PD0325901.


Before opening, briefly centrifuge the vial to ensure full recovery of sample. Aliquotting the stock solution is recommended to avoid repetitive freeze-thaw cycles. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%.

  1. Bain, J., Plater, L., Elliott, M., Hastie, C.J., McLauchlan, H., Klevernic, I., Arthur, J.S., Alessi, D.R., and Cohen, P. The selectivity of protein kinase inhibitors: a further update. Biochem J 408: 297-315 (2007).
  2. Sebolt-Leopold, J.S. and Herrera, R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947 (2004).
  3. Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A., and Ding, S. A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808 (2009).

Additional Publications