Stemgent Stemolecule Sodium Butyrate

Code: 04-0005-base
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Sodium butyrate is the sodium salt of the short-chain fatty acid butyric acid. It is a metabolite of intestinal bacteria, a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract1. Sodium butyrate is also a known inhibitor of histone deacetylases (HDACs)2. HDAC inhibitors are promising anti-tumour agents that work by inhibiting cell proliferation and survival3. Along with the cytokines Activin A and acidic fibroblast growth factor (aFGF), sodium butyrate has been shown to direct the differentiation of mouse embryonic stem (ES) cells into hepatocytes4. Sodium butyrate has also been reported to increase the efficiency of transfection and expression for both transient and stable transfections5.


Product Name

Stemolecule Sodium Butyrate

Catalog Number



500 mg

Alternate Name(s)

Butyric acid sodium salt

Chemical Formula


Molecular Weight


CAS Number



Greater than 98% by acid base titration


White solid


This molecule is soluble in water at 900 mM.


For a 100 mM stock solution of Sodium Butyrate, add 9 mL of water to 100 mg of the compound. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the medium should be prewarmed prior to adding sodium butyrate.

Storage and Stability

Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. For Sodium Butyrate, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control

The purity of Sodium Butyrate was determined by acid-base titration. The accurate mass was determined by mass spectrometry. Cellular toxicity of Sodium Butyrate was tested on HeLa and HEK293 cells.

Specification Sheets

Safety Data Sheets

  1. Säemann, M.D., Böhmig, G.A., Osterreicher, C.H., Burtscher, H., Parolini, O., Diakos, C., Stöckl, J., Hörl, W.H., Zlabinger, G.J. Anti-inflamatory effects of sodium butyrate on human monocytes: Potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J 14: 2380-2382 (2000).
  2. Kruh, J. Effecs of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 42: 65-82 (1982).
  3. Mühlethaler-Mottet, A., Meier, R., Flahaut, M., KBourloud, K.B., Nardou, K., Joseph, J.M., and Gross, N. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumor activity in neuroblastoma cells. Mol Cancer 7: 55 (2008).
  4. Zhou, M., Li, P., Tan, L., Qu, S., Ying, Q.L., Song, H. Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J Cell Biochem 109: 606-614 (2010).
  5. Goding, C.R., and Russell, W.C. S1 sensitive sites in adenovirus DNA. Nucleic Acids Res 11: 21-36 (1983).

Additional Publications