Stemolecule Thiazovivin
Stemgent

Stemolecule Thiazovivin

QTY Cat # Size Unit Price
04-0017 1 mg $285.00

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Overview

Thiazovivin is a selective, cell-permeable small molecule that directly targets Rho-associated kinase (ROCK)1. In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin-mediated cell-cell interaction1. This observation suggests that Thiazovivin promotes cell survival. In other studies, Thiazovivin, in combination with inhibitors of the TGFβ receptor and MEK pathway, has been shown to improve reprogramming efficiency by more than 200-fold2.

Documents

Sds 04 0017 thiazovivin v1.2
References
  1. Xu, Y., Zhu, X., Hahm, H.S., Wei, W., Hao, E., Hayek, A., and Ding, S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci USA 107: 8129-8134 (2010).
  2. Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A., and Ding, S. A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808 (2009).