Stemgent Stemolecule Wnt Inhibitor IWP-4

Code: 04-0036-base
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Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.

New 50 mg size now available.

Product Name

Stemolecule Wnt Inhibitor IWP-4

Catalog Number



2 mg

Alternate Name(s)


Chemical Formula


Molecular Weight


CAS Number



Greater than 96% by HPLC analysis


White solid


This molecule is reported to be soluble in DMSO at 1.2 mM.


For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell culture, keep the total DMSO concentration less than 0.1%.

Storage and Stability

Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at − 20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control

The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-4 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets