Stemgent Stemolecule Wnt Inhibitor IWP-4

Code: 04-0036-base
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Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.

New 50 mg size now available.

Product Name

Stemolecule Wnt Inhibitor IWP-4

Catalog Number



2 mg

Alternate Name(s)


Chemical Formula


Molecular Weight


CAS Number



Greater than 96% by HPLC analysis


White solid


This molecule is reported to be soluble in DMSO at 1.2 mM.


For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell culture, keep the total DMSO concentration less than 0.1%.

Storage and Stability

Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at − 20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control

The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-4 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets

  1. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107 (2009).

Additional Publications